Overview
A peptide your mitochondria themselves encode, a cousin of MOTS-c.
It protects cells from stress and death, supports metabolism, and is studied for neuroprotection and longevity.
Levels fall with age.
What It Does
Humanin is a 24-amino-acid mitochondrial-derived peptide (the analog HNG / S14G-humanin is more potent).
It is cytoprotective and anti-apoptotic, improves insulin sensitivity, and protects neurons; originally discovered as a factor shielding cells from Alzheimer’s-related death.
No formal human clinical dose; community use is extrapolated from animal data.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 2 mL | 5 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–6 | Daily or several×/week | 0.5–2 mg | SubQ. Start at the low end. Research/community range, no validated human dose. |
| Off | 2–4 weeks | – | Cycle 4–8 weeks on / 2–4 weeks off. |
4–8 weeks on / 2–4 weeks off.
any time; pairs naturally with MOTS-c as a mitochondrial stack. Note: no completed human trials, effects are inferred from animal/longevity research.
Unisex mitochondrial-derived peptide, no sex-specific dosing; research-stage. Avoid in pregnancy.
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~2–3 weeks (structure-based estimate, no published data); potency fades before the 28-day sterility limit, so keep it cold and dark and use it sooner.
- Subtle metabolic and cytoprotective support over weeks; a longevity/recovery adjunct rather than an acute-effect peptide.
- Supply math 10mg → 5 vials (6-wk @ 1 mg/day; fewer if dosed several×/week)
Safety & Patient Education
- Fasting glucose / metabolic panel if used for metabolic goals Age-appropriate cancer screening if used long-term Out of range?
- Rising glucose/HbA1c = blood sugar creeping up (recheck, adjust).
