Overview
Humanin is a 24-amino-acid mitochondrial-derived peptide (MDP) that functions as a systemic cytoprotective and anti-aging signaling molecule.
What problem it targets: It targets mitochondrial dysfunction, age-related cognitive decline, endothelial blood vessel damage, neurodegeneration (Alzheimer's models), and cellular oxidative stress.
What It Does
• Protects mitochondria from apoptosis: Binds and neutralizes pro-apoptotic proteins like BAX, preventing stressed cells from triggering premature cell suicide.
• Shields brain cells and blood vessels: Inhibits beta-amyloid toxicity in neurons and enhances endothelial nitric oxide production, protecting vascular health and brain perfusion.
• Enhances whole-body insulin sensitivity: Acts on hypothalamic receptors to improve metabolic signaling, lowering blood glucose and reducing visceral fat accumulation in research models.
• Realistic expectations: Humanin is a cellular health and longevity-oriented peptide. Its benefits manifest internally as improved mitochondrial resilience and metabolic balance rather than acute physical stimulation.
Reconstitution
| Vial size | BAC water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 2 mL | 5 mg/mL |
Protocol
| Phase | Frequency | Dose | Units (5 mg/mL) | Notes |
|---|---|---|---|---|
| Weeks 1–6 | Daily or several×/week | 0.5–2 mg | 10–40u | SubQ. Start at the low end. Research/community range, no validated human dose. |
| Off | 2–4 weeks | – | – | Cycle 4–8 weeks on / 2–4 weeks off. Cycle: 4–8 weeks on / 2–4 weeks off. Timing: any time; pairs naturally with MOTS-c as a mitochondrial stack. Note: no completed human trials, effects are inferred from animal/longevity research. By sex: Unisex mitochondrial-derived peptide, no sex-specific dosing; research-stage. Avoid in pregnancy. |
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~2–3 weeks (structure-based estimate, no published data); potency fades before the 28-day sterility limit, so keep it cold and dark and use it sooner.
- Subtle metabolic and cytoprotective support over weeks; a longevity/recovery adjunct rather than an acute-effect peptide.
- Supply math 10mg → 5 vials (6-wk @ 1 mg/day; fewer if dosed several×/week)
Safety & Patient Education
- Fasting glucose / metabolic panel if used for metabolic goals Age-appropriate cancer screening if used long-term Out of range?
- Rising glucose/HbA1c = blood sugar creeping up (recheck, adjust).
