Overview
Mechano Growth Factor, a splice variant of IGF-1 your muscles release when damaged by training.
It tells satellite (stem) cells to multiply and repair the muscle.
Native MGF lasts only minutes, so it’s injected straight into the worked muscle right after training.
What It Does
MGF (IGF-1Ec) activates muscle satellite cells, driving proliferation and local repair/hypertrophy after mechanical damage.
Its half-life is only ~5–7 minutes, so it must be injected locally into the target muscle within minutes of the last set.
For systemic/longer action, use the pegylated version (PEG-MGF).
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 2 mg | + 1 mL | 2 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Training days | Post-workout | 200–400 mcg | IM directly into the trained muscle within 5–10 min of the last set (half-life is minutes). |
| Off days | – | – | No benefit off training days for native MGF, the stimulus is the workout. |
run during training blocks, 6–8 weeks, then break.
immediately post-workout, local to the worked muscle; this is the whole point of native (non-PEG) MGF. Note: if you want a wider dosing window or systemic effect, use PEG-MGF instead.
A local IGF-1 splice variant, like the GH axis, women may respond at a slightly lower dose. Efficacy contested; avoid in pregnancy.
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F, best used within ~2–3 weeks (structure-based estimate), away from light; a small linear peptide with no PEG shielding, so slightly shorter than the default.
- Enhanced local recovery and hypertrophy in the trained muscle over a training block.
- Effects are local and modest, not dramatic.
- Supply math 2mg → 4 vials (8-wk @ 200 mcg, ~4 training days/wk)
Safety & Patient Education
- Efficacy is contested, a rigorous two-lab replication (Fornaro 2014) found the MGF peptide failed to affect muscle-cell proliferation or differentiation, questioning whether it has a real physiological effect.
- Treat benefits as unproven.
- IGF-family growth signaling, theoretical tumor-promotion concern Local, short-acting; benefit is limited to the injected muscle Limited human data; quality varies, request a COA
- IGF-1 if used heavily or stacked with GH-axis peptides Age-appropriate cancer screening if used long-term Out of range?
- If you stack it with GH-axis peptides, IGF-1 above your age range = too much growth signal → back off.
