Overview
NAD Buffer is a sterile, specialized pharmaceutical buffering diluent designed to neutralize the sharp acidity of reconstituted NAD+ solutions.
What problem it targets: It eliminates the intense burning, stinging, and localized tissue irritation that typically accompanies subcutaneous and intramuscular NAD+ injections.
What It Does
• Balances injection pH to physiological levels: Raises the naturally acidic pH of raw NAD+ (which often sits between 2.0 and 3.0) closer to the body's neutral 7.0–7.4 range.
• Minimizes injection site discomfort: Neutralizing the solution eliminates the acute burning, inflammation, and subcutaneous lump formation common with unbuffered NAD+.
• Preserves molecule integrity: Specifically formulated not to degrade or hydrolyze the delicate NAD+ dinucleotide structure during storage.
• Realistic expectations: Used in place of standard sterile water during mixing. Does not change the biological action of NAD+, but transforms an otherwise painful injection into a comfortable experience.
Reconstitution
| Vial size | BAC water / Solvent | Concentration |
|---|---|---|
| 500 mg | + 1 mL | 500 mg/mL |
| 1000 mg | + 2 mL | 500 mg/mL |
Protocol
| Phase | Frequency | Dose | Units (100 mg/mL) | Notes |
|---|---|---|---|---|
| Weeks 1–2 (ramp) | 2–3×/week | 25–50 mg | 25–50u | SubQ, injected SLOWLY. Buffering helps, but slow is still key. |
| Weeks 3+ | 2–3×/week | 50–100 mg | 50–100u | Titrate up by tolerance. Still inject slowly to minimize flushing. Cycle: ongoing or 8–12 week blocks. Timing: daytime (can be energizing). Key: the buffer reduces discomfort, but slow injection remains the main way to avoid the flush/chest-tightness; never push a bolus. By sex: N/A, a buffer / reagent for reconstitution, not a dosed compound. |
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within 28 days.
- Protect from light.
- NAD buffer is just pH-adjusted NAD+, so it fades the way NAD+ does; the honest limit is potency at ~10–14 days refrigerated and dark (glycosidic and pyrophosphate hydrolysis), well before the 28-day sterility cap, matching this guide's NAD+ page.
