Overview
MGF with a polyethylene-glycol (PEG) coat that stretches its lifespan from minutes to 2–3 days.
That means you can inject it subcutaneously on a schedule (not jammed into the muscle seconds after a set) and it works systemically.
What It Does
PEG-MGF is pegylated Mechano Growth Factor.
The PEG coat resists breakdown, extending half-life to ~48–72 hours and allowing systemic satellite-cell activation and recovery support with convenient SubQ dosing 2–3×/week.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 2 mg | + 1 mL | 2 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–8 | 2–3×/week | 200–400 mcg | SubQ. On training days, dose within 1–2 h post-workout for best effect. |
| Off | 4 weeks | – | Standard break between blocks. |
6–8 weeks on / 4 weeks off.
the long half-life gives a wide window, post-workout on training days, anytime on rest days. SubQ; no need to inject into a specific muscle. Note: complements native MGF (immediate local) with systemic coverage.
Pegylated MGF (longer half-life), like MGF, women may need slightly less. Efficacy contested; avoid in pregnancy.
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F, best used within ~3–4 weeks (structure-based estimate), away from light; PEG slows clearance in the body but does not extend the vial window.
Safety & Patient Education
- Efficacy is contested, a rigorous replication (Fornaro 2014) found the MGF peptide had no effect on muscle cells.
- Treat benefits as unproven.
- IGF-family growth signaling, theoretical tumor-promotion concern, more relevant with systemic (PEG) exposure Limited human data; quality varies, request a COA
- IGF-1 if used heavily or stacked Age-appropriate cancer screening if used long-term Out of range?
- If you stack it with GH-axis peptides, IGF-1 above your age range = too much growth signal → back off.
