Overview
The vitamin you can’t get from plants.
Injected for energy, mood, and methylation; especially useful for vegans, people on metformin, and anyone over 60.
What It Does
Essential B-vitamin for nerve function, red blood cell formation, and energy metabolism.
Cofactor for methionine synthase (methylation) and methylmalonyl-CoA mutase (energy metabolism).
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 2.5 mL | 4 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Deficiency loading | Daily ×7 then weekly | 1,000 mcg | Target serum B12 400–900 pg/mL. |
| Maintenance | Monthly | 1,000 mcg | Once repleted. |
| MIC protocol | M/W/F | 1 mg/mL in blend | As component of lipotropic blend. |
monthly maintenance ongoing. Loading: 1000 mcg daily x 7 days then weekly x 4 weeks for deficiency. No cycling required for maintenance.
Weekly IM (maintenance); daily for repletion phase
Unisex, same dosing for anyone; no cycle effect. Safe and commonly used in pregnancy at normal doses.
Handling & Stacking
- Solution: room temp or refrigerated.
- Use within 30 days.
- Protect from light.
- B12's a stable small molecule that lasts months in the dark, but once a multidose vial is punctured the honest community and compounding limit is sterility at ~28–30 days refrigerated, so go by that and keep it out of light.
- Energy improvement within days of loading in deficient individuals.
- Neurological symptoms may improve over 4–8 weeks.
- Target serum B12: 400– 900 pg/mL.
- Supply math 10mg → 3 vials (4-wk @ 1000 mcg × 7/wk)
Safety & Patient Education
- Compound-specific: CBC + reticulocyte count (baseline → reticulocytosis by Day 3–10 confirms response and macrocytic-anemia resolution) Serum B12 (baseline + Week 8; target 400–900 pg/mL); MMA + homocysteine if neurological symptoms Serum potassium when correcting significant deficiency (hypokalemia can appear in the first week as new red cells form, per the FDA label); iron + folate baseline (a deficiency can surface once B12 repletes) Out of range?
- Low B12 = deficiency (fatigue, tingling, brain fog) → keep supplementing until it's mid-range; a dropping potassium early in treatment = it's shifting into the new red cells → replace it.
