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AHK-Cu

A copper peptide closely related to GHK-Cu, but more associated with hair; it promotes hair-follicle growth and blood-vessel support around the follicle. Used topically as a scalp serum (see the separate GHK-Cu topical guide for formulation mechanics).

Research referenceCommunity compiled

Molecular profile

The molecule itself: sequence, composition, mass, target, and registry identifiers.

Molecular formula
C₁₅H₂₄ClCuN₆O₄-
Average mass
451.39 Da
CAS number
682809-81-0
Registry
PubChem CID 168431292
Receptor / pathway
Copper transportno receptor
Formula, mass and identifiers from PubChem CID 168431292.
Research & reference information

This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.

Overview

AHK-Cu is a specialized copper-tripeptide complex formulated primarily to stimulate hair follicles, boost scalp vascularity, and slow hair thinning.

What problem it targets: It targets male and female pattern hair loss, follicle miniaturization, sluggish hair growth cycles, and scalp collagen degradation.

What It Does

• Stimulates dermal papilla cell proliferation: Encourages the growth and activity of cells at the base of hair follicles, expanding follicle size and anchoring root depth.

• Promotes microvascular blood flow: Upregulates vascular endothelial growth factor (VEGF), delivering fresh blood, oxygen, and micronutrients directly to dormant follicles.

• Inhibits hair follicle apoptosis: Protects follicles against premature transition into the catagen (shedding) phase, prolonging the active anagen (growth) cycle.

• Realistic expectations: Primarily evaluated as a topical scalp serum or mesotherapy agent. Visible improvements in hair thickness and shed reduction typically require 3 to 6 months of consistent application.

Topical Formulation

VialCarrierTarget %Note
50 mgDistilled water + glycol scalp serum0.05–1%50 mg makes ~5–10 mL at 0.5–1%. Use the same recipe/cautions as the GHK-Cu scalp serum.
100 mgAs above0.05–1%100 mg makes ~10–20 mL at 0.5–1%.

Use Protocol

PhaseFrequencyApplicationNotes
OngoingOnce daily (PM)Few drops massaged into thinning scalp areasLeave on. Judge at 3–6 months. Often stacked with minoxidil (different time of day). Cycle: continuous; assess at 3–6 months. Timing: dry/damp scalp at night; a 0.5 mm dermaroller 1–2×/week boosts penetration. Note: keep away from vitamin C / acids (breaks the copper complex); can pair with GHK-Cu. By sex: Unisex topical copper peptide, used the same by anyone; watch cumulative copper with heavy use. Confirm with a prescriber in pregnancy.

Handling & Stacking

Application
Topical scalp serum. Patch-test for copper sensitivity.
Storage
  • Powder: -4°F.
  • Mixed serum: 36–46°F; preserve if stored.
  • Bright blue = fresh; faded or brown = remake.
  • Potency runs ~2–4 weeks (community estimate), copper-oxidation limited, so keep it cold and dark.
Side effects
Minimal, occasional scalp irritation; faint blue staining of light hair (rinses out).
What to expect
  • Gradual hair-follicle support over 3–6 months; best as a minoxidil adjunct rather than a standalone.
  • Supply math 50mg → ~1 scalp-serum batch | 100mg → ~2 batches (see GHK-Cu topical guide)
Pairs well with
GHK-Cu (copper-peptide hair stack); minoxidil (different time of day); microneedling
Avoid
Vitamin C / AHA-BHA / benzoyl peroxide same session (breaks copper complex). Broken/irritated scalp. Pregnancy
Approved drug
Tretinoin (Renova) is FDA-approved for fine wrinkles and Botox for frown lines, both far better evidenced than cosmetic peptides.

Safety & Patient Education

Contraindications
Copper sensitivity / Wilson’s disease Broken or inflamed scalp Pregnancy and lactation
Warnings
Topical cosmetic, patch-test for copper allergy Acids/oxidizers in the same session disrupt the copper complex Standalone hair-regrowth evidence is modest, best as an adjunct Unpreserved serum spoils, preserve or refrigerate
Drug interactions
Topical vitamin C / acids / benzoyl peroxide: chemical incompatibility (space them apart) None systemic
Labs
None, cosmetic topical
Stop criteria
Persistent scalp irritation Allergic/copper-sensitivity reaction
Patient education
Topical scalp serum, see the GHK-Cu topical guide for recipe and cautions Patch-test; keep away from vitamin C / acids Give it 3–6 months; pair with minoxidil + microneedling Bright blue means fresh, remake if it fades
References
researchdosing · peptidedosages · PubMed