Overview
A pregnancy hormone that looks like LH to your body.
Men on TRT use it to keep their testicles working and stay fertile.
What It Does
Human Chorionic Gonadotropin, mimics LH to maintain testicular function and testosterone during suppressive cycles.
Binds LH/CG receptors on Leydig cells to stimulate testosterone production.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 1000 iu | + 0.5 mL | 2000 IU/mL |
| 2000 iu | + 1 mL | 2000 IU/mL |
| 5000 iu | + 2.5 mL | 2000 IU/mL |
| 10000 iu | + 5 mL | 2000 IU/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Standard | Mon/Wed/Fri | 250 IU | LH-mimetic, maintains testosterone. |
| Higher | Mon/Wed/Fri | 500 IU | At this dose, estrogen (E2) elevation is more likely. Have an AI available and test at Week 4. |
| Fertility | Daily or | 500–1,000 | Full fertility support dose. This protocol takes 70+ days to show results in sperm counts. |
| FDA | 3×/wk | 500–1,000 | FDA Pregnyl/Novarel male-hypogonadism dose (or 4,000 → 2,000 IU 3×/wk). The 250 IU “Standard” above is a lower |
| label | IU | 50u |
TRT-adjunct: ongoing while on TRT (no scheduled off-cycle). Fertility: 70+ day cycle (one full spermatogenesis cycle). Single-dose ovulation trigger: one IM injection per IVF cycle (per FDA Pregnyl / Novarel labels).
2–3×/week SubQ, anytime; same days each week.
Acts like LH, an ovulation trigger and luteal support, timed to the cycle. Men: Mimics LH so the testes make their own testosterone and sperm; low-dose ~250–500 IU every other day keeps intratesticular T and fertility, even on Acts like LH, an ovulation trigger and luteal support, timed to the cycle. Men: Mimics LH so the testes make their own testosterone and sperm; low-dose ~250–500 IU every other day keeps intratesticular T and fertility, even on TRT.
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within 28 days.
- No clear reconstituted-potency data (the label lists only an in-use date, not potency), so defer to the 28-day sterility limit.
- Testicular volume maintenance and testosterone support within days.
- Monitor estrogen, HCG raises both T and E2.
- Supply math 1000iu → 15 vials | 2000iu → 8 vials | 5000iu → 3 vials | 10000iu → 2 vials (10-wk @ 500 iu × 3/wk)
Safety & Patient Education
- Estradiol elevation common; AI may be needed (monitoring mandatory).
- Thromboembolic risk with elevated E2.
- OHSS in females can be life-threatening.
- Mood changes, gynecomastia in males.
- Precocious puberty in males with cryptorchidism.
- AIs (anastrozole, letrozole): manage E2; over-suppression worsens lipids/bone.
- SERMs (clomiphene, tamoxifen, enclomiphene): redundant HPG overlap.
- Exogenous testosterone: shuts down LH/FSH, reduces HCG efficacy unless TRT paused/microdosed.
- Anticoagulants: elevated E2 raises thrombotic risk.
- Insulin/antidiabetics: monitor glucose at high doses.
- E2 (baseline + Wk 4–6); total + free testosterone, LH, FSH, sensitive E2 (baseline/mid/end); SHBG + prolactin baseline; CBC + hematocrit (polycythemia); lipid panel; PSA (men >40); semen analysis baseline + quarterly (fertility); D-dimer if clotting symptoms., Out of range?
- Low testosterone or high estradiol = the hormone axis needs tuning; hematocrit >54% = blood too thick (donate or hold).
- Watch for clotting symptoms (leg swelling, calf/chest pain, sudden dyspnea).
- Estrogen side effects manageable with an AI under physician guidance.
- Fertility: 70+ days before semen analysis changes.
- Recon math reflects community TRT-adjunct / PCT use (multi-dose SubQ); FDA labels (Pregnyl, Novarel, Ovidrel) describe single-use IM only; off-label is community-standard but unlabeled.
- HCG is a licensed biologic (2020 BPCIA), compounding requires a biologics license; US Pregnyl/Novarel supply is intermittent (2026).
