Overview
Tells your pituitary to fire off LH and FSH, which restarts your natural hormone system.
Has to be dosed in pulses (like M/W/F), daily shuts it down.
What It Does
HPG axis activator, stimulates GnRH release to naturally drive testosterone, FSH, and libido through the body’s own hormonal cascade.
Activates GPR54 in the hypothalamus, triggering GnRH → LH + FSH surge → testosterone.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 5 mg | + 1 mL | 5 mg/mL |
| 10 mg | + 2 mL | 5 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Standard | M/W/F | 100–200 | 3.0–6.0u Community standard SubQ bolus. Daily dosing causes GPR54 desensitisation; pulsatile cadence |
| Fertility | M/W/F or | 200–400 | 6.0–12.0u HPG restoration. Higher dose for stronger LH/FSH surge. Avoid daily dosing. |
| Off | 30 days | – | – Natural HPG reset. |
30-day cycles, 30-day off.
3×/week SubQ pulsatile, never daily (GPR54 desensitization). Dose note: human IV data (George 2011) shows max LH at ~1 µg/kg (~70 mcg/70 kg); ~3 µg/kg gave a reduced response. SubQ bioavailability differs, so don’t escalate past observed LH/libido response.
The LH/FSH response is hugely cycle-dependent, over 100× stronger just before ovulation. Timing is everything. Men: Raises LH and testosterone and speeds LH pulses, investigational for low-T and low lib The LH/FSH response is hugely cycle-dependent, over 100× stronger just before ovulation. Timing is everything. Men: Raises LH and testosterone and speeds LH pulses, investigational for low-T and low libido.
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~2–3 weeks (structure-based estimate, no published data); potency fades before the 28-day sterility limit, so keep it cold and dark and use it sooner.
Safety & Patient Education
- Estradiol elevation possible; AI may be needed.
- Thromboembolic risk with elevated E2.
- OHSS in females can be life-threatening.
- Mood changes, gynecomastia in males.
- Daily dosing causes GPR54 desensitization, pulsatile dosing only.
- AIs (anastrozole, letrozole): manage E2; over-suppression worsens lipids/bone.
- SERMs (clomiphene, tamoxifen, enclomiphene): redundant HPG overlap.
- Exogenous testosterone: shuts down LH/FSH, reduces efficacy unless TRT paused/microdosed.
- Anticoagulants: elevated E2 raises thrombotic risk.
- Insulin/antidiabetics: monitor glucose at high doses.
- Total + free testosterone (baseline + end), LH + FSH (Day 0/10/30), sensitive E2 (baseline/mid/end); SHBG + prolactin baseline; CBC + hematocrit; lipid panel; PSA (men >40); semen analysis baseline + quarterly (fertility); D-dimer if clotting symptoms., Out of range?
- Low testosterone or high estradiol = the hormone axis needs tuning; hematocrit >54% = blood too thick (donate or hold).
- Watch for clotting symptoms (leg swelling, calf/chest pain, sudden dyspnea).
- Estrogen side effects manageable with an AI under physician guidance.
- Fertility: 70+ days before semen analysis changes.
- 3×/week maximum, avoid daily dosing (GPR54 desensitization).
