Overview
A small peptide modeled on CNTF (a nerve growth factor).
It pushes the brain to grow new neurons and make more BDNF, studied for memory and Alzheimer’s in animals.
Usually taken as a nasal spray so it reaches the brain directly.
Cumulative; effects build over weeks.
What It Does
P21 (P021) is a CNTF-derived neurotrophic tetrapeptide mimetic.
It promotes neurogenesis, raises BDNF, inhibits leptin-pathway-linked tau pathology, and shows disease-modifying effects in Alzheimer’s models.
Intranasal delivery exploits nose-to-brain transport, bypassing the blood-brain barrier.
No completed human trials.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 5 mg | + 2.5 mL | 2 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–6 | Daily | 250–500 mcg SubQ or 500 mcg–1 mg intranasal | Intranasal is the common route. Effects are cumulative. |
| Off | 2–4 weeks | – | Cycle 4–8 weeks on / 2–4 weeks off. Caution: no completed human trials, doses are user/animal-derived. |
daytime; neurogenic effects build over weeks, do not expect immediate changes. Route: intranasal gives direct nose-to-brain delivery; SubQ also used.
Unisex experimental neurogenic peptide, animal data only, no sex-specific dosing. Avoid in pregnancy.
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~3–4 weeks, kept cold (community estimate, no published data); that is close to the 28-day sterility limit, so use whichever comes first.
- Gradual memory/cognitive support over weeks if effective; cumulative.
- Strongest rationale is in age-related cognitive decline (animal models).
- Supply math 5mg → 2 vials (6-wk @ 250 mcg/day SubQ; more if intranasal mg-dosing)
