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Cognitive and Neuroprotective

DSIP

A natural sleep peptide. Pushes you toward deeper sleep and tones down nighttime stress hormones. Inject before bed.

Research referenceCommunity compiled
Research & reference information

This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.

Overview

A natural sleep peptide.

Pushes you toward deeper sleep and tones down nighttime stress hormones.

Inject before bed.

What It Does

Delta Sleep-Inducing Peptide, promotes slow-wave (delta) sleep, reduces stress hormones, and regulates circadian rhythm.

Modulates CRH.

May regulate pineal.

Reconstitution

Vial SizeBAC Water / SolventConcentration
2 mg+ 0.4 mL5 mg/mL
5 mg+ 1 mL5 mg/mL
10 mg+ 2 mL5 mg/mL
Interactive tool

Reconstitution Calculator

Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.

Calculated concentration—Enter both values above.
Optional conversion

Enter a target amount you already have and select the syringe capacity.

Calculated draw—Enter concentration inputs and a target amount.

Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.

Protocol

PhaseFrequencyAmountNotes
Weeks 1–2Nightly200 mcg6.0u Start low and assess how your body responds before increasing.
Weeks 3–8Nightly200–500 mcg6.0–15.0u Effective range.
Off2–4 weeks–– Essential break between cycles. Skipping leads to tolerance and diminishing returns.
Cycle & Timing

4–8 weeks on, 2–4 weeks off.

Timing

Pre-bed nightly, 15–30 min before sleep.

Evidence Context

minimal human data; no dosing RCT.

Population Considerations

Unisex sleep peptide, same protocol for men and women, no cycle effect.

Handling & Stacking

Injection site
SubQ abdomen.
Storage
  • Freeze-dried: -4°F.
  • Reconstituted: 36–46°F.
  • Best used within ~10–14 days (structure-based estimate, no published data); potency fades before the 28- day sterility limit, so keep it cold and dark and use it sooner.
  • Protect from light.
Side effects
Sedation (expected), headache (occasional), vivid dreams.
What to expect
  • Deeper, more restorative sleep typically within the first few doses.
  • Reduced overnight cortisol.
  • Vivid dreams in some users.
  • Supply math 2mg → 12 vials | 5mg → 5 vials | 10mg → 3 vials (8-wk @ 500 mcg × 7/wk)
Pairs well with
Melatonin (sleep architecture); Glycine (deep-sleep amplification); GHK-Cu (recovery during sleep)
Avoid
Active or history of cancer (theoretical GH-related concern). Pregnancy / nursing
Approved drug
Approved insomnia drugs: the orexin blockers suvorexant (Belsomra), lemborexant (Dayvigo) and daridorexant (Quviviq); low-dose doxepin (Silenor); ramelteon (Rozerem); and zolpidem.

Safety & Patient Education

Contraindications
Pregnancy, lactation, active or history of cancer (theoretical GH-related concern)
Warnings
Limited human data. PCAC REJECTED it (as “emideltide”) from the 503A bulks list, 6–7 (Jul 2026); the only one of seven peptides voted down.
Drug interactions
CNS depressants (benzodiazepines, Z-drugs, barbiturates, opioids, alcohol): additive sedation; avoid same-night combo or reduce dose Other sleep agents (melatonin, Epithalon): redundant rather than additive; pick one per cycle Sedating antidepressants (mirtazapine, trazodone, doxepin, amitriptyline): additive sedation; coordinate timing Stimulants (caffeine, ADHD meds): mechanistically opposed; not harmful but blunts effect Antihypertensives: theoretical additive nocturnal BP drop, monitor if combining at high doses
Labs
Compound-specific: CBC + CMP baseline; no compound-specific markers routinely required
Stop criteria
Excessive sedation, vivid dreams disturbing sleep, persistent daytime grogginess
References
researchdosing · peptidedosages · PubMed · thepeptidereport · peptides.id