Overview
Vasoactive Intestinal Peptide, a signaling hormone your body makes that calms inflammation and regulates the immune system, blood vessels, and hormones.
Used as a compounded nasal spray, mostly in the final stage of the CIRS (mold/biotoxin illness) protocol.
What It Does
VIP is a 28-amino-acid neuropeptide with broad anti-inflammatory, immune-regulating, and vasoactive effects.
In the Shoemaker CIRS protocol it’s the final-stage agent used to restore regulatory neuropeptide function after upstream steps are complete.
Intranasal delivery; not FDA-evaluated.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 5 mg | + 2.5 mL | 2 mg/mL |
| 10 mg | + 5 mL | 2 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
PROTOCOL (SHOEMAKER CIRS)
| Phase | Frequency | Dose | Per administration | Notes |
|---|---|---|---|---|
| Weeks 1–12 | Up to 4×/day | 50 mcg per nostril | ~50–100 mcg/dose | Intranasal. Start lower; titrate. Course 30–90 days, then taper toward zero. |
| Taper | Reduce frequency | – | – | Goal is to gradually reduce to zero as regulation is restored. Prereqs (CIRS): VIP is the last step, only after passing a VCS test and treating MARCoNS (nasal staph) per the protocol. Using it out of sequence can backfire. Note: compounded VIP is not FDA-evaluated for safety or efficacy. By sex: Largely unisex (immune / anti-inflammatory), dose by protocol. A uterine relaxant / vasoactive, avoid in pregnancy. Limited self-use data. |
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: refrigerate 36–46°F; nasal bottle best used within ~7–14 days (structure-based estimate); potency fades before the 28- day sterility limit.
- Protect from light.
- Improved inflammatory markers, energy, and quality of life in CIRS when used correctly at the end of the protocol.
- Not a standalone fix.
- Supply math 5mg → 3 vials | 10mg → 2 vials (60-day course @ ~100–200 mcg/day)
Safety & Patient Education
- Compound-specific: Serum lipase at baseline and periodically (Shoemaker's intranasal VIP protocol won't start if lipase is elevated – pancreatitis is the defining risk) CIRS labs per Shoemaker (TGF-β1, C4a, MMP-9, VIP level) Blood pressure monitoring, especially the first dose Out of range?
- Rising lipase = pancreatic irritation → stop VIP; a big first-dose BP drop = ease off.
