Earn points on every order · Free shipping on orders over $159 · New products in stock
← Back to Compound Library
Fat Loss and Metabolism

5-Amino-1MQ

Stops your body from burning through its own energy fuel so fat-burning runs more efficiently.

Research referenceCommunity compiled
Research & reference information

This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.

Overview

Stops your body from burning through its own energy fuel so fat-burning runs more efficiently.

What It Does

Blocks NNMT enzyme to support fat metabolism, cellular energy, and NAD+ preservation.

Inhibits Nicotinamide N-methyltransferase (NNMT), reducing NAD+ consumption and increasing SIRT1/AMPK activity.

Reconstitution

Vial SizeBAC Water / SolventConcentration
5 mg+ 0.25 mL20 mg/mL
10 mg+ 0.50 mL20 mg/mL
50 mg+ 2.5 mL20 mg/mL
Interactive tool

Reconstitution Calculator

Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.

Calculated concentration—Enter both values above.
Optional conversion

Enter a target amount you already have and select the syringe capacity.

Calculated draw—Enter concentration inputs and a target amount.

Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.

Protocol

PhaseFrequencyAmountNotes
Weeks 1–Daily AM2.5Tolerance check. SC abdomen or thigh. Assess GI tolerance and stimulation before stepping up.
Weeks 3–Daily or twice5 mgWorking dose. Half-life 3.8–6.9 h, so splitting into two daily doses gives steadier NNMT inhibition. Hold here if Weeks 1–2
Off4 weeks–Standard
Cycle & Timing

8 weeks on, 4 weeks off. Extended: 12 on, 6 off. Cycle: 6–8 weeks on, 2–4 weeks off.

Timing

AM only, stimulating; avoid evening doses (sleep disruption).

Population Considerations

Unisex metabolic (NNMT inhibitor), same protocol for men and women, no cycle effect.

Handling & Stacking

Injection site
Abdomen or outer thigh.
Storage
  • Freeze-dried: -4°F (up to 24 months).
  • Reconstituted: 36–46°F.
  • Best used within 28 days for sterility; the molecule itself stays stable well beyond that (small molecule, not a fragile peptide).
  • No freeze-thaw.
Side effects
Appetite suppression, mild stimulation, injection-site stinging.
What to expect
  • Mild appetite suppression and slight stimulation within 1–2 hours.
  • Fat loss is gradual, most noticeable at 6–8 weeks with consistent caloric deficit.
  • Supply math 5mg → 49 vials | 10mg → 25 vials | 50mg → 5 vials (8-wk @ 5 mg × 7/wk)
Pairs well with
NAD+ (preserves injected NAD+ via NNMT inhibition); MOTS-c (overlapping metabolic pathways); Tirzepatide / Semaglutide (NNMT + GLP-1 synergy)
Avoid
Metformin or Berberine (additive AMPK activation risks significant glucose drops)
Approved drug
Approved weight-loss drugs are far better proven: semaglutide (Wegovy), tirzepatide (Zepbound), orforglipron (Foundayo, oral, 2026), plus phentermine, Qsymia, Contrave and orlistat.

Safety & Patient Education

Contraindications
No human safety data; pregnancy, lactation, pediatrics excluded. Active malignancy (NAD+ pathway interactions theoretical).
Warnings
NNMT inhibition broadly affects methylation. Long-term safety unknown.
Drug interactions
Metformin and berberine (additive AMPK activation, glucose drops); hard contraindication during the same dosing window.
Labs
  • Compound-specific: Fasting glucose + HbA1c (baseline + end), lipid panel (Week 0/12), Out of range?
  • Rising glucose/HbA1c = blood sugar creeping up (recheck, adjust diet); worsening lipids = reassess the fat-loss protocol.
Stop criteria
Persistent hypoglycemia, unexplained fatigue, mood changes
Patient education
NAD+ pathway effects are theoretical based on cell and animal data.
References
researchdosing · peptidedosages · PubMed · thepeptidereport