Overview
A long-acting version of amylin, the fullness hormone your pancreas releases alongside insulin.
Slows stomach emptying and curbs appetite.
Often paired with semaglutide (the “CagriSema” combo) for additive weight loss.
What It Does
Cagrilintide is a long-acting amylin analog.
It signals satiety, slows gastric emptying, and reduces food intake through a mechanism complementary to GLP-1 drugs; which is why amylin + GLP- 1 stacks outperform either alone.
Once-weekly dosing.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 2 mg | + 0.4 mL | 5 mg/mL |
| 5 mg | + 1 mL | 5 mg/mL |
| 10 mg | + 2 mL | 5 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–4 | Once weekly | 0.25 mg | Titrate slowly, nausea is dose-dependent. |
| Weeks 5–8 | Once weekly | 0.5 mg | |
| Weeks 9–12 | Once weekly | 1.0 mg | |
| Weeks 13–16 | Once weekly | 1.7 mg | |
| Week 17+ | Once weekly | 2.4 mg | Research-target maintenance. Do not exceed ~4.5 mg/week. |
titrate over 16–20 weeks to the 2.4 mg maintenance dose; escalate only when the current dose is well tolerated.
same day each week, any time, with or without food. Rotate injection sites. Stack: commonly combined with semaglutide (CagriSema), titrate the two together and expect stronger GI effects.
Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving. Men: In men, excess fat lowers testosterone; GLP-1 raises testosterone, SHBG and gonadotropins as weight drops, improves sperm and erectile function, and preserves fertility (unlike T Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving. Men: In men, excess fat lowers testosterone; GLP-1 raises testosterone, SHBG and gonadotropins as weight drops, improves sperm and erectile function, and preserves fertility (unlike TRT).
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~2–4 weeks, kept cold (structure-based estimate, no published data); that is close to the 28- day sterility limit, so use whichever comes first.
- Earlier satiety and smaller portions within weeks; steady weight loss over months (strongest with a GLP-1).
- Supply math 2mg → 7 vials | 5mg → 3 vials | 10mg → 2 vials (16-wk titration to 2.4 mg/wk)
Safety & Patient Education
- Fasting glucose / HbA1c (baseline + periodic), especially if diabetic Renal function if significant vomiting/diarrhea Weight, blood pressure, heart rate trend Out of range?
- Rising glucose/HbA1c = creeping toward diabetes (recheck, tighten diet); falling eGFR = kidney strain, usually dehydration (hydrate, hold).
