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Fat Loss and Metabolism

AOD-9604

A small fragment of growth hormone (the tail end, residues 176–191) that keeps GH’s fat-burning signal but not its blood-sugar or IGF- 1 effects. So it nudges fat metabolism without the insulin-resistance or tumor-growth concerns of full GH.

Research referenceCommunity compiled
Research & reference information

This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.

Overview

A small fragment of growth hormone (the tail end, residues 176–191) that keeps GH’s fat-burning signal but not its blood-sugar or IGF- 1 effects.

So it nudges fat metabolism without the insulin-resistance or tumor-growth concerns of full GH.

What It Does

AOD-9604 is the C-terminal GH fragment (176–191).

It stimulates lipolysis and inhibits lipogenesis via beta-3 adrenergic signaling without raising IGF-1 or affecting glucose, the key distinction from GH- axis peptides.

Mild, additive fat-loss tool rather than a standalone heavyweight.

Reconstitution

Vial SizeBAC Water / SolventConcentration
2 mg+ 0.4 mL5 mg/mL
5 mg+ 1 mL5 mg/mL
10 mg+ 2 mL5 mg/mL
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Protocol

PhaseFrequencyAmountNotes
Weeks 1–8Daily (5 on / 2 off)300 mcgAM, fasted, into abdominal fat. 300–500 mcg range; 300 is standard.
Off4–8 weeks–Weekly 2-day break during the cycle helps avoid receptor desensitization.
Cycle & Timing

8–12 weeks on (5 days on / 2 off each week) / 4–8 weeks off.

Timing

first thing AM on an empty stomach, fasted state favors fat oxidation. Note: does not raise IGF-1 or glucose, so it lacks the GH-class metabolic warnings.

Population Considerations

Unisex (a GH fragment for fat loss without GH’s growth signaling), same protocol for men and women, no cycle effect. Avoid in pregnancy.

Handling & Stacking

Injection site
SubQ, abdomen. Rotate.
Storage
Freeze-dried: -4°F. Reconstituted: 36–46°F. Best used within 28 days, otherwise potency gradually fades over ~3–4 weeks (community estimate, no published data).
Side effects
Generally minimal, occasional injection-site reaction or mild headache. No appetite, glucose, or IGF-1 effect.
What to expect
  • Subtle, gradual fat-loss support over 8–12 weeks; best as an adjunct to diet/training or stacked with a GLP-1 or GH peptide, not a standalone fix.
  • Supply math 2mg → 6 vials | 5mg → 3 vials | 10mg → 2 vials (8-wk @ 300 mcg, 5/wk)
Pairs well with
Semaglutide / Tirzepatide (appetite + lipolysis); Tesamorelin / CJC + Ipamorelin (GH-axis fat loss); Lipo-C / L-Carnitine
Avoid
Pregnancy. (No major interactions, one of the more benign fat-loss peptides)
Approved drug
Approved weight-loss drugs are far better proven: semaglutide (Wegovy), tirzepatide (Zepbound), orforglipron (Foundayo, oral, 2026), plus phentermine, Qsymia, Contrave and orlistat.

Safety & Patient Education

Contraindications
Pregnancy and lactation Hypersensitivity to the peptide
Warnings
Does not raise IGF-1 or glucose, lacks the usual GH-class metabolic risks, but human efficacy data are modest Quality varies between sources, request a COA Marketed claims often exceed the evidence, treat as an adjunct
Drug interactions
No significant known interactions Stacks cleanly with GLP-1s and GH-axis peptides
Labs
None compound-specific required; general metabolic panel if part of a larger fat-loss protocol Weight / body-composition tracking
Stop criteria
Persistent injection-site reactions Any unexpected systemic reaction Pregnancy
Patient education
One of the gentler fat-loss peptides, no blood-sugar or IGF-1 impact Effects are subtle; it works best alongside diet, training, or a stronger agent Fasted AM dosing is standard Source quality matters, request a COA
References
researchdosing · peptidedosages · PubMed · thepeptidereport