Overview
Adipotide (Prohibitin-Targeting Peptide / FTPP) is an experimental peptidomimetic designed to target and eliminate white adipose tissue by starving its blood supply.
What problem it targets: It was created to treat morbid obesity and severe metabolic dysfunction by directly shrinking visceral and subcutaneous fat depots that resist diet and exercise.
What It Does
• Homes in on fat-tissue blood vessels: The targeting domain binds specifically to prohibitin, a protein uniquely expressed on the endothelial surface of white fat capillaries.
• Triggers targeted blood vessel destruction: Its apoptotic domain disrupts mitochondrial membranes in those vessel cells, cutting off oxygen and nutrients to neighboring fat cells.
• Rapidly reduces white fat volume: Starved fat cells undergo programmed cell death and are reabsorbed and cleared by the body, resulting in marked weight reduction in animal studies.
• Realistic expectations: While extraordinarily potent at eliminating fat in primate trials, it exhibits significant, dose-dependent renal stress and kidney toxicity that have restricted human viability.
Reconstitution
| Vial size | BAC water / Solvent | Concentration | Note |
|---|---|---|---|
| 2 mg | + 0.4 mL | 5 mg/mL | No validated human dose, figures are research-derived only |
| 5 mg | + 1 mL | 5 mg/mL | |
| 10 mg | + 2 mL | 5 mg/mL |
Protocol
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F, best used within ~2–3 weeks (structure-based estimate); potency fades before the 28-day sterility limit, so keep it cold, dark, and use it sooner.
- Unknown in humans.
- Animal data showed rapid fat loss but with kidney injury, the risk/benefit is not established.
- Supply math Not applicable, no validated human dosing.
- Research compound only.
Safety & Patient Education
- Renal function (creatinine, eGFR, urinalysis) before, during, and after; mandatory if used at all Electrolytes and hydration status Out of range?
- Any creatinine rise or eGFR drop = kidney injury starting → stop immediately (this is the defining risk).
