Overview
CJC-1295 (No DAC) + Ipamorelin is the gold-standard dual-action synergy blend designed to maximize natural growth hormone production.
What problem it targets: It solves the progressive age-related drop in growth hormone (somatopause), accelerating tissue repair, sleep restoration, fat loss, and muscle recovery.
What It Does
• Unleashes dual-pathway GH synergy: CJC-1295 stimulates the GHRH pathway while Ipamorelin activates the ghrelin/growth hormone secretagogue receptor (GHS-R), producing up to a 5x greater GH release than either peptide alone.
• Blunts somatostatin (the GH off-switch): Ipamorelin suppresses somatostatin while CJC triggers pituitary secretion, allowing an unhindered, maximal natural GH pulse.
• Clean, side-effect-free profile: Ipamorelin does not elevate prolactin, cortisol, or ACTH, avoiding the intense hunger, water retention, and anxiety seen with older GHRPs.
• Realistic expectations: Improves deep REM and slow-wave sleep within the first 1 to 2 weeks; fat reduction, tighter skin, and faster recovery become prominent after 8 to 12 weeks of nightly use.
Reconstitution
| Vial size | BAC water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 3 mL | 3.33 mg/mL |
Protocol
| Phase | Frequency | Dose | Notes |
|---|---|---|---|
| Weeks 1–2 | Nightly pre-bed | 200 mcg | Start low and assess how your body responds before increasing. |
| Weeks 3–12 | Nightly pre-bed | 400 mcg | Standard effective dose for most users. |
| Off | 4 weeks | – | Off period, let your pituitary and receptors recover before the next cycle. Cycle: 12 weeks on / 4 weeks off. Max 16 weeks on / 4–8 weeks off; receptor desensitization beyond 16 weeks continuous. Timing: Fasted, pre-bed is standard; the pulse lands with the natural deep-sleep GH release, which is why this stack is the go-to for sleep + recovery. No food 90 min before / 60 min after; fasted AM works if pre-bed is impractical. Sleep: GHRH promotes slow-wave sleep, most notice deeper sleep in 1–2 weeks. Women: Women make ~3× the GH of men yet have similar IGF-1, they’re less responsive, so often need a higher dose to move IGF-1. Oral estrogen blunts IGF-1 further (read it as running low); a skin patch/gel is more predictable. Men: Men convert GH to IGF-1 more efficiently and more often overshoot the age ceiling (a higher malignancy signal), aim mid-normal for age, don’t chase the top. |
Handling & Stacking
Safety & Patient Education
- Compound-specific: IGF-1 (baseline + Week 8 + end), Lipid panel (Week 0/12) IGF-1 at baseline, mid-cycle, and end of cycle.
- Target ULN for age Fasting glucose and HbA1c at baseline and end of cycle Mammogram and prostate screening per age-appropriate guidelines before starting Out of range?
- IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.
