Overview
A strong GH-releaser that works through the hunger-hormone (ghrelin) receptor.
Hits GH harder than Ipamorelin, with less appetite than GHRP-6; pairs with a GHRH like Sermorelin/CJC for a bigger combined pulse.
What It Does
GHRP-2 (pralmorelin) is a ghrelin-mimetic GH secretagogue (GHS-R1a agonist).
It amplifies the GH pulse and, combined with a GHRH analog, produces a markedly larger release than either alone.
Mildly raises cortisol and prolactin and stimulates appetite, less than GHRP-6, more than Ipamorelin.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 5 mg | + 1 mL | 5 mg/mL |
| 10 mg | + 2 mL | 5 mg/mL |
| 15 mg | + 3 mL | 5 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–2 | 2×/day | 100 mcg | AM fasted + pre-bed. Start low; assess flushing and tolerance. |
| Weeks 3–12 | 2–3×/day | 200 mcg | Working dose. ~1 mcg/kg per dose is the saturating range, more raises cortisol/prolactin without more GH. |
| Off | 4 weeks | – | Prevents ghrelin-receptor downregulation. |
8–12 weeks on / 4 weeks off.
Empty stomach, no food 30 min after, ideally 2–3 h since last meal. Carbs/fats blunt the pulse. Pair each dose with a GHRH for synergy. Saturation: dose plateaus ~1 mcg/kg; going higher mostly adds cortisol/prolactin.
Women need more GH but get a bigger bump from ghrelin-types, though these raise prolactin, which can disrupt cycles/ovulation (watch for missed periods). Oral estrogen blunts IGF-1. Men: Men overshoot the IGF-1 ceiling more easily (aim mid-normal); high prolactin lowers libido and testosterone, switch to a cleaner option if it cli Women need more GH but get a bigger bump from ghrelin-types, though these raise prolactin, which can disrupt cycles/ovulation (watch for missed periods). Oral estrogen blunts IGF-1. Men: Men overshoot the IGF-1 ceiling more easily (aim mid-normal); high prolactin lowers libido and testosterone, switch to a cleaner option if it climbs.
Handling & Stacking
- Improved sleep and recovery within 1–2 weeks; body-composition changes over 8–12 weeks.
- Strongest as part of a GHRH + GHRP stack.
- Supply math 5mg → 7 vials | 10mg → 4 vials | 15mg → 3 vials (12-wk @ 200 mcg × 2/day)
Safety & Patient Education
- IGF-1 (baseline + Week 8 + end).
- Target upper-normal for age Fasting glucose / HbA1c (baseline + end) Prolactin if symptomatic (galactorrhea, low libido) Age-appropriate cancer screening before starting Out of range?
- IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.
