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Growth Hormone Axis

CJC-1295 (No DAC)

A short-acting version. Each shot gives you about a 30-minute GH pulse. Usually paired with Ipamorelin.

Research referenceCommunity compiled
Research & reference information

This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.

Overview

A short-acting version.

Each shot gives you about a 30-minute GH pulse.

Usually paired with Ipamorelin.

What It Does

GHRH analog producing natural pulsatile GH release when injected pre-bed.

Short half-life = clean GH pulse.

Binds GHRH receptors on pituitary somatotrophs.

Reconstitution

Vial SizeBAC Water / SolventConcentration
5 mg+ 1 mL5 mg/mL
10 mg+ 2 mL5 mg/mL
Interactive tool

Reconstitution Calculator

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Protocol

PhaseFrequencyAmountNotes
Weeks 1–2Nightly 5×/week200 mcg6.0u Start low and assess how your body responds before increasing.
Weeks 3–12Nightly 5×/week300 mcg9.0u Standard effective dose for most users.
Off4 weeks–– Off period, let your pituitary and receptors recover before the next cycle.
Cycle & Timing

8–12 weeks on / 4 weeks off. Max: 12 weeks on / 4–8 weeks off. 5 nights/week (M–F) preferred over daily.

Timing

Fasted AM or fasted pre-bed. No food 60–90 min before; no food 60 min after, food-driven insulin blunts the GH pulse. Dose note: GHRH receptors saturate near ~100 mcg; 300 mcg adds little extra GH, mostly cost.

Population Considerations

Women make ~3× the GH of men yet have similar IGF-1, they’re less responsive, so often need a higher dose to move IGF-1. Oral estrogen blunts IGF-1 further (read it as running low); a skin patch/gel is more predictable. Men: Men convert GH to IGF-1 more efficiently and more often overshoot the age ceiling (a higher malignancy signal), aim mid-normal for age, don’t chase the Women make ~3× the GH of men yet have similar IGF-1, they’re less responsive, so often need a higher dose to move IGF-1. Oral estrogen blunts IGF-1 further (read it as running low); a skin patch/gel is more predictable. Men: Men convert GH to IGF-1 more efficiently and more often overshoot the age ceiling (a higher malignancy signal), aim mid-normal for age, don’t chase the top.

Handling & Stacking

Injection site
Abdomen. Can combine with Ipamorelin in same syringe.
Storage
Freeze-dried: -4°F. Reconstituted: 36–46°F. Best used within 28 days, otherwise potency gradually fades over ~4–6 weeks (structure-based estimate, no published data).
Side effects
Water retention, tingling, mild fatigue.
What to expect
Better sleep by 1–2 wks, recovery by 4–6, body-composition change by 8–12 wks. Supply math 5mg → 4 vials | 10mg → 2 vials (12-wk @ 300 mcg × 5/wk)
Pairs well with
Ipamorelin (canonical GHRH + GHRP synergy); GHRP-2 / GHRP-6 / Hexarelin (GH pulse amplification); Wolverine Blend (BPC-157 + TB-500) (recovery stack); IGF-1 LR3 (downstream IGF amplification)
Avoid
Long-acting glucocorticoids (suppress GH axis). Active malignancy (GH may promote growth)
Approved drug
Somatropin (HGH) is approved for growth-hormone deficiency and tesamorelin (Egrifta) for HIV lipodystrophy. Secretagogues like this one are off-label.

Safety & Patient Education

Contraindications
Active malignancy of any kind (GH/IGF-1 can promote tumor growth) Severe diabetic retinopathy Acute critical illness (per somatropin label, applies to GH-axis stimulators) Pregnancy and lactation
Warnings
Insulin resistance and worsening glycemic control with sustained use Fluid retention, peripheral edema Carpal tunnel syndrome with extended use Joint and muscle pain IGF-1 elevation: theoretical malignancy promotion if dosed beyond physiological IGF-1 ranges
Drug interactions
Glucocorticoids: blunt GH response, minimize or time away from injection Insulin / antidiabetics: GH worsens insulin resistance, expect dose adjustments + tighter monitoring Levothyroxine: GH lowers free T4, recheck TSH/fT4 quarterly Oral estrogens: blunt GH-stimulated IGF-1, transdermal doesn’t
Labs
  • IGF-1 (baseline / mid / end; target ULN for age), Lipid panel (Week 0/12) Fasting glucose and HbA1c at baseline and end of cycle Mammogram and prostate screening per age-appropriate guidelines before starting Out of range?
  • IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.
Stop criteria
Fasting glucose rises >20 mg/dL above baseline IGF-1 rises above the upper limit of normal for age New persistent joint pain or carpal tunnel symptoms New skin changes or moles enlarging Vision changes
Patient education
GH-axis stimulation is not appropriate during active malignancy or for fertility Most GH pulses occur during deep sleep, dose pre-bed unless instructed otherwise Food within 90 min of injection blunts GH response (carbs/fats most), fasted is standard
References
researchdosing · peptidedosages · PubMed · thepeptidereport · peptides.id · Span 2000 · Weissberger 1991