Overview
The most potent of the GHRP family per microgram, but it also burns out its own receptors fastest.
Run it in short, hard cycles, not continuously.
What It Does
Hexarelin is a highly potent GHS-R1a agonist with the strongest GH-releasing punch of the GHRPs and minimal appetite effect.
Its high binding affinity drives the fastest receptor desensitization of any GHRP, so its window of usefulness is short.
Mild cortisol/prolactin rise; some cardioprotective signaling in research.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 2 mg | + 1 mL | 2 mg/mL |
| 5 mg | + 2.5 mL | 2 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–6 | 1–2×/day | 100 mcg | Working dose. ~1 mcg/kg saturates; do not chase higher. Fasted. |
| Off | 6–8 weeks | – | Longer off than other GHRPs, receptors need more time to re-sensitize. |
4–6 weeks on / 6–8 weeks off (shorter on, longer off than other GHRPs). Running it longer cuts response by 45%+ as receptors downregulate.
Empty stomach, AM and/or pre-bed. Saturation: ~1 mcg/kg, higher doses accelerate desensitization without more GH.
Women are less responsive to GH (need more), and these ghrelin-types give a bigger GH bump in women; but they raise prolactin, which can disrupt the cycle/ovulation (watch for missed periods). Oral estrogen also blunts IGF-1. Men: Men overshoot the IGF-1 ceiling more easily (aim mid-normal). High prolactin from GHRPs lowers libido and testosterone in men, switch to a clean option if it cli Women are less responsive to GH (need more), and these ghrelin-types give a bigger GH bump in women; but they raise prolactin, which can disrupt the cycle/ovulation (watch for missed periods). Oral estrogen also blunts IGF-1. Men: Men overshoot the IGF-1 ceiling more easily (aim mid-normal). High prolactin from GHRPs lowers libido and testosterone in men, switch to a clean option if it climbs.
Handling & Stacking
- Fast, strong GH response early in the cycle; benefit tapers as receptors desensitize; hence short cycles.
- Minimal appetite vs GHRP-6.
- Supply math 2mg → 5 vials | 5mg → 2 vials (6-wk @ 100 mcg × 2/day)
Safety & Patient Education
- IGF-1 (baseline + end of the short cycle) Fasting glucose / HbA1c (baseline + end) Prolactin if symptomatic Age-appropriate cancer screening before starting Out of range?
- IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.
