Overview
Another GLP-1 + glucagon dual agonist, like survodutide, but generally smoother on the stomach.
Curbs appetite and nudges up energy expenditure.
What It Does
Mazdutide is a GLP-1 / glucagon receptor dual agonist (an OXM-based analog).
GLP-1 drives satiety and slowed gastric emptying; glucagon adds energy expenditure and hepatic fat effects.
Reported to be less nausea-inducing than survodutide.
Once-weekly with a simple 4-step titration.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 2 mL | 5 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–4 | Once weekly | 1.5 mg | Start here; smoother GI profile than survodutide. |
| Weeks 5–8 | Once weekly | 3 mg | |
| Weeks 9–12 | Once weekly | 4.5 mg | |
| Week 13+ | Once weekly | 6 mg | Maintenance. Many cap at 4–6 mg, especially if stacked. |
4-step titration over ~12–16 weeks to 6 mg/week maintenance; each step lasts 4 weeks.
same day each week, any time. Note: still raises heart rate via glucagon agonism, monitor.
Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving. Men: In men, excess fat lowers testosterone; GLP-1 raises total testosterone, SHBG and gonadotropins as weight drops, and improves sperm and erectile function; and preserves fertility, unlike TRT (which suppresses spe Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving. Men: In men, excess fat lowers testosterone; GLP-1 raises total testosterone, SHBG and gonadotropins as weight drops, and improves sperm and erectile function; and preserves fertility, unlike TRT (which suppresses sperm).
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~3–4 weeks, kept cold (structure-based estimate, no published data); that is close to the 28- day sterility limit, so use whichever comes first.
- Appetite suppression plus a metabolic-rate effect; steady weight loss over months.
- Investigational outside its approval region.
- Supply math 10mg → 6 vials (16-wk titration to 6 mg/wk)
Safety & Patient Education
- Fasting glucose / HbA1c (baseline + periodic) Liver enzymes; lipase if pancreatitis suspected Resting heart rate / blood pressure Renal function with significant GI losses Out of range?
- Rising glucose/HbA1c = blood sugar creeping toward diabetes (recheck, tighten diet); a falling eGFR = kidney strain, usually dehydration (hydrate, hold the dose).
