Gives you a deep tan. Side effects include nausea, a libido boost, and unprompted erections. Keep an eye on your moles, they darken too.
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Research & reference information
This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.
Overview
Gives you a deep tan.
Side effects include nausea, a libido boost, and unprompted erections.
Keep an eye on your moles, they darken too.
What It Does
Non-selective melanocortin agonist, increases melanin (tanning) and libido via MC4R.
Parent compound of PT-141.
Activates MC1R (melanogenesis), MC3R (energy), and MC4R (sexual arousal).
Reconstitution
Vial Size
BAC Water / Solvent
Concentration
10 mg
+ 3 mL
3.33 mg/mL
Interactive tool
Reconstitution Calculator
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Optional conversion
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Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
Phase
Frequency
Amount
Notes
Load Week 1
Nightly
167 mcg
Start low.
Load Week 2
Nightly
333 mcg
Step up.
Maintenance
1–2×/week
500 mcg
Sustain pigmentation.
Cycle & Timing
2-week loading phase then ongoing maintenance.
Timing
Daily SubQ during loading; anytime; libido use 1–2 hr before activity.
Evidence Context
not approved; afamelanotide is the only approved α-MSH analog. Reviews flag melanoma/mole risk.
Population Considerations
Melanocortin effects hit both sexes: skin/mole darkening (melanoma monitoring), nausea, appetite drop. MT-2 also raises libido/arousal (same MC4R pathway as PT-141).
Handling & Stacking
Injection site
SubQ abdomen. Rotate.
Storage
Freeze-dried: -4°F. Reconstituted: 36–46°F. Best used within 28 days, otherwise potency gradually fades over ~6–8 weeks (inferred from a marketed analog). Protect from light.
Side effects
Flushing/nausea (dose-dependent, resolves). Darkening of all pigmented lesions. Libido increase.
What to expect
Skin darkens within days; flushing/nausea at loading (ease with titration); spontaneous erections in men. Monitor all moles. Supply math 10mg → 1 vial (2-wk @ 500 mcg × 2/wk)
Personal or family history of melanoma. Atypical mole syndrome. Recent prolonged unprotected sun exposure
Safety & Patient Education
Contraindications
Personal or family history of melanoma Atypical mole syndrome / dysplastic nevus syndrome Active skin cancer or pre-malignant skin lesions Uncontrolled hypertension Cardiovascular disease (significant) Pregnancy and lactation
Warnings
Hyperpigmentation of all melanocytes including existing moles, mole monitoring required New mole formation Transient BP elevation (PT-141: mean ~6 mmHg systolic per FDA Vyleesi label) Nausea, especially MT-2 during loading Priapism risk in men (MT-2 specifically) Spontaneous erections (MT-2) Reduced response and tachyphylaxis with frequent use Priapism risk in men.
Spontaneous erections expected.
Greater pigmentation magnitude than MT-1.
Drug interactions
PDE5 inhibitors (sildenafil, tadalafil, vardenafil): additive BP effects with PT-141; separate timing per label Antihypertensives: additive or paradoxical BP effects Vasoactive drugs in general
Labs
Dermatology mole mapping (photo-documented) at baseline + ABCDE recheck every 12 weeks on-cycle, then every 6–12 months Blood pressure log at baseline and before each dose
Stop criteria
New atypical mole or rapid change in existing mole (ABCDE criteria) Sustained BP elevation above 140/90 in previously normotensive patient Priapism (sustained erection more than 4 hours): seek emergency care Severe nausea not resolving with dose reduction
Patient education
Use sunscreen during MT-1/MT-2, extra melanin doesn’t replace UV protection Photograph moles at baseline; recheck monthly ABCDE warning signs: Asymmetry, Border irregularity, Color variation, Diameter >6mm, Evolution MT-2: erections are pharmacologic, >4 hours is a medical emergency PT-141: do not exceed 1 dose per 24 hours
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