Overview
Melanotan II (MT-2) is a potent, non-selective cyclic analogue of alpha-melanocyte-stimulating hormone that stimulates skin tanning while strongly boosting libido.
What problem it targets: It targets fair skin prone to severe sunburning, inability to tan, and central psychogenic and physical erectile dysfunction or low sexual desire.
What It Does
• Stimulates rapid melanin production (MC1R): Signals skin melanocytes to produce rich, dark eumelanin, producing a deep tan with very little sun exposure.
• Ignites central libido and erections (MC4R): Crosses into the central nervous system to activate MC4R in the hypothalamus, triggering spontaneous sexual arousal and robust erections in men and women.
• Suppresses appetite: Activation of central melanocortin pathways produces moderate appetite suppression during active administration.
• Realistic expectations: MT-2 is fast-acting and potent. Common initial side effects include mild nausea, facial flushing, and darkening of existing moles and freckles; starting with conservative micro-doses is crucial.
Reconstitution
| Vial size | BAC water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 3 mL | 3.33 mg/mL |
Protocol
| Phase | Frequency | Dose | Notes |
|---|---|---|---|
| Load Week 1 | Nightly | 167 mcg | Start low. |
| Load Week 2 | Nightly | 333 mcg | Step up. |
| Maintenance | 1–2×/week | 500 mcg | Sustain pigmentation. Cycle: 2-week loading phase then ongoing maintenance. Timing: Daily SubQ during loading; anytime; libido use 1–2 hr before activity. Evidence: not approved; afamelanotide is the only approved α-MSH analog. Reviews flag melanoma/mole risk. By sex: Melanocortin effects hit both sexes: skin/mole darkening (melanoma monitoring), nausea, appetite drop. MT-2 also raises libido/arousal (same MC4R pathway as PT-141). |
Handling & Stacking
Safety & Patient Education
- Hyperpigmentation of all melanocytes including existing moles, mole monitoring required New mole formation Transient BP elevation (PT-141: mean ~6 mmHg systolic per FDA Vyleesi label) Nausea, especially MT-2 during loading Priapism risk in men (MT-2 specifically) Spontaneous erections (MT-2) Reduced response and tachyphylaxis with frequent use Priapism risk in men.
- Spontaneous erections expected.
- Greater pigmentation magnitude than MT-1.
