A classic ‘lipotropic’ shot, methionine, inositol, choline, and B12. Used 2–3× a week as a fat-loss helper.
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Research & reference information
This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.
Overview
A classic ‘lipotropic’ shot, methionine, inositol, choline, and B12.
Used 2–3× a week as a fat-loss helper.
What It Does
Classic MIC + B12 lipotropic, Methionine + Inositol + Choline + B12 for hepatic fat metabolism and energy.
Methionine: fat transport and detox.
Inositol: lipid metabolism and insulin signalling.
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Unisex lipotropic (methionine / inositol / choline), dose by protocol. Avoid in pregnancy.
Handling & Stacking
Injection site
SubQ or IM upper outer thigh.
Storage
Solution: refrigerate.
Use within 30 days.
Community and compounding-pharmacy practice both cap a reconstituted MIC blend at ~28–30 days refrigerated on sterility and slow oxidation, not peptide potency, so toss it at the 28-day mark even if there's fluid left.
B-vitamin allergy. Severe hepatic disease (choline metabolism)
Approved drug
Approved weight-loss drugs are far better proven: semaglutide (Wegovy), tirzepatide (Zepbound), orforglipron (Foundayo, oral, 2026), plus phentermine, Qsymia, Contrave and orlistat.
Safety & Patient Education
Contraindications
Component allergies (B12, riboflavin, lecithin, choline, methionine, lidocaine) Hypothyroid medication, separate by 4 hours Severe hepatic impairment (choline metabolism) Pregnancy and lactation, specific compounding required Bleeding disorders or anticoagulants (relative), bruising risk
Warnings
Compounded products, composition varies; request the pharmacy’s COA B12 (cyanocobalamin) contains cobalt, allergy possible Methionine elevates homocysteine in some individuals L-Carnitine: TMAO conversion concern in CV disease (controversial, baseline lipids) Injection-site reactions common with phosphatidylcholine
Drug interactions
Warfarin: L-carnitine and choline blends can potentiate, monitor INR if combining Levothyroxine: separate by 4 hours, choline/B-vitamins affect absorption Anticoagulants / antiplatelets (DOACs, aspirin, clopidogrel): bruising risk with phosphatidylcholine Insulin / antidiabetics: B-complex may shift glucose, recheck log if dosing changes Methotrexate, trimethoprim, phenytoin: deplete folate / B12; coordinate with prescriber Lidocaine blends (LC526): avoid other caines same session, additive cardiac effects Stimulants / phentermine: additive CV load with high-dose lipotropics, monitor BP/HR
Labs
Compound-specific: Liver enzymes AST/ALT (baseline), baseline hepatic function before starting Baseline B12, folate, MMA, homocysteine (methylation markers) TSH at baseline (B12 deficiency masks hypothyroidism) Liver enzymes (choline metabolism) Hematocrit (B12 raises RBC, polycythemia risk in some)
Patient education
Fishy odor from choline/L-carnitine is normal, not allergic Inject slowly to reduce stinging Don’t use with warfarin without physician guidance (potentiation risk) Request exact ingredient list and concentrations from your compounder
References
peptidedosages · PubMed · thepeptidereport
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