Overview
Tricks your cells into acting like you just exercised.
People use it for energy, fat-burning, and better insulin response.
What It Does
Mitochondria-derived peptide that activates AMPK for metabolic health, energy, and insulin sensitivity.
Encoded in the 12S rRNA of mtDNA.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 0.50 mL | 20 mg/mL |
| 40 mg | + 2 mL | 20 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Standard | M/W/F AM | 5 mg | Working dose. Exercise-mimetic, pair with training days if possible. Some sources run a lower 5–10 mg/week total; this 5 mg ×3 (15 mg/week) sits at the higher end of the community range. |
| Off | 4 weeks | – | Break by convention, and it limits injection-site nodules (the documented issue for this class). Tolerance is often claimed but has never been tested. |
4–6 wks on (5 mg 3×/wk) / 4 wks off.
Fasted AM (M/W/F) or fasted 30–60 min pre-workout; no food 60–90 min before / 60 min after, exercise-mimetic; avoid evening doses.
Unisex mitochondrial peptide, same protocol for men and women, no cycle effect. Avoid in pregnancy.
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~2–4 weeks (community estimate; vendor data shows >99% purity through Day 14 and under 98% by Day 30), kept cold and dark; two oxidation-prone residues make it fragile, so use it sooner.
- Never freeze reconstituted.
- Early AMPK-driven fatigue and appetite suppression in weeks 1–2 (expected, resolves).
- Improved metabolic function builds over the cycle.
- Monitor fasting glucose when stacked with 5-Amino and NAD+.
- Supply math 10mg → 6 vials | 40mg → 2 vials (4-wk @ 5 mg × 3/wk)
Safety & Patient Education
- First human efficacy RCT now registered (Phase 2a, NCT07505745, prediabetes + overweight/obesity); no completed or published human efficacy data yet.
- AMPK activation overlaps with metformin and berberine.
- PCAC RECOMMENDED it for the 503A bulks list, 7–5 (Jul 2026; advisory, non-binding; FDA rulemaking pending).
- Fasting glucose + fasting insulin (Week 0/4/8), HbA1c and lipid panel (baseline + end)., Out of range?
- MOTS-C should push glucose and insulin the right way – if fasting glucose/HbA1c keep climbing instead, recheck and tighten diet; there's no routine kidney concern with this one.
- Aseptic technique; single-use sterile needle each injection; never share vials/needles.
- Sharps in an FDA-cleared container.
- Maintain cold chain; mark first-puncture date; inspect every vial before use.
- Rotate injection sites.
