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Cognitive and Neuroprotective

Selank

Russian anti-anxiety peptide. Calms you down without making you drowsy.

Research referenceCommunity compiled
Research & reference information

This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.

Overview

Russian anti-anxiety peptide.

Calms you down without making you drowsy.

What It Does

Anxiolytic nootropic, Russian pharmaceutical for anxiety and cognitive enhancement.

Approved in Russia for anxiety disorders.

Tuftsin analog modulating GABAergic and serotonergic systems.

Inhibits enkephalin-degrading enzymes.

Stimulates BDNF and NGF.

Reconstitution

Vial SizeBAC Water / SolventConcentration
5 mg+ 1 mL5 mg/mL
10 mg+ 2 mL5 mg/mL
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Protocol

PhaseFrequencyAmountNotes
IntranasalDaily AM250–500 mcg2.5–5 sprays Dissolve and spray.
SubQDaily AM250–500 mcg7.5–15.0u Systemic alternative.
Off2 weeks–– Prevents tolerance.
Cycle & Timing

4–6 weeks on, 2 weeks off.

Timing

Daily SubQ, anytime; calmer than Semax.

Route / Related Reference

Selank (Intranasal) for the nasal-route page.

Evidence Context

Russian-approved (anxiety); no completed Western clinical trials.

Population Considerations

Unisex anxiolytic nootropic, no meaningful sex or cycle effect; same protocol for men and women. Avoid in pregnancy.

Handling & Stacking

Injection site
Intranasal (primary). SubQ abdomen (alternative).
Storage
Freeze-dried or solution: refrigerate. Best used within ~6–8 weeks (structure-based estimate); a robust proline-rich peptide, so 28 days is conservative.
Side effects
Mild sedation or relaxation. Rarely: headache. Generally very well tolerated.
What to expect
  • Anxiolytic effect within 20–30 min of intranasal.
  • Clear-headed calmness, not sedating.
  • Memory and focus improvement over 2–4 weeks.
  • No addiction or withdrawal.
  • Supply math 5mg → 3 vials | 10mg → 2 vials (4-wk @ 500 mcg × 7/wk)
Pairs well with
Semax (synergistic nootropic / mood support); BPC-157 (neuroregeneration); GHK-Cu (neuroprotective complement); L-Theanine (calming amplification)
Avoid
MAOIs (theoretical serotonergic interaction). Active psychosis / bipolar mania
Approved drug
  • For anxiety the approved options are SSRIs (sertraline, escitalopram), SNRIs (venlafaxine, duloxetine) and buspirone; all with large trial bases.
  • This peptide has no Western approval or RCT.

Safety & Patient Education

Contraindications
Active psychosis or mania MAOI therapy (theoretical serotonergic interaction) Pregnancy and lactation
Warnings
Approved in Russia / Ukraine / some CIS states, not FDA-approved Quality varies between research-chemical and pharmaceutical-grade suppliers Headache common in initial days (Semax), often responds to choline
Drug interactions
MAOIs: avoid SSRIs/SNRIs: theoretical serotonergic risk, monitor for serotonin syndrome Stimulants: additive activation, reduce dose if combined Sedatives/benzodiazepines: Selank may augment GABA effects
Labs
Compound-specific: CBC + CMP baseline; no compound-specific markers routinely required
Patient education
Neuroactive compounds, effects are real and dosing matters Don’t combine with prescription antidepressants without physician input Russian clinical practice: 10–14 day courses, not continuous
References
researchdosing · peptidedosages · PubMed · thepeptidereport