Overview
Selank is a synthetic heptapeptide derived from the endogenous immunopeptide tuftsin, developed as an allosteric modulator of GABA and a potent anxiolytic.
What problem it targets: It targets generalized anxiety disorder (GAD), chronic psychological stress, mental exhaustion, social unease, and cognitive sluggishness.
What It Does
• Relieves anxiety without sedation: Modulates GABAergic neurotransmission to melt away anxiety and panic without causing muscle weakness, drowsiness, or brain fog.
• Upregulates BDNF and memory function: Stimulates Brain-Derived Neurotrophic Factor in the hippocampus, enhancing learning, focus, and emotional resilience under stress.
• Balances monoamine neurotransmitters: Regulates serotonin, dopamine, and norepinephrine metabolism, producing a calm, clear-headed state of flow.
• Realistic expectations: Does not cause physical dependence, tolerance, or withdrawal like benzodiazepines. Delivered subcutaneously; reduces stress within 15 to 30 minutes while cognitive benefits build over weeks.
Reconstitution
| Vial size | BAC water / Solvent | Concentration |
|---|---|---|
| 5 mg | + 1 mL | 5 mg/mL |
| 10 mg | + 2 mL | 5 mg/mL |
Protocol
| Phase | Frequency | Dose | Units (2.5 mg/mL) | Units (3.33 mg/mL) | Notes |
|---|---|---|---|---|---|
| Intranasal | Daily AM | 250–500 mcg | 2.5–5 sprays | 2.5–5 sprays | Dissolve and spray. |
| SubQ | Daily AM | 250–500 mcg | 10–20u | 7.5–15.0u | Systemic alternative. |
| Off | 2 weeks | – | – | – | Prevents tolerance. Cycle: 4–6 weeks on, 2 weeks off. Timing: Daily SubQ, anytime; calmer than Semax. See Selank (Intranasal) for the nasal-route page. Evidence: Russian-approved (anxiety); no completed Western clinical trials. By sex: Unisex anxiolytic nootropic, no meaningful sex or cycle effect; same protocol for men and women. Avoid in pregnancy. |
Handling & Stacking
- Anxiolytic effect within 20–30 min of intranasal.
- Clear-headed calmness, not sedating.
- Memory and focus improvement over 2–4 weeks.
- No addiction or withdrawal.
- Supply math 5mg → 3 vials | 10mg → 2 vials (4-wk @ 500 mcg × 7/wk)
- For anxiety the approved options are SSRIs (sertraline, escitalopram), SNRIs (venlafaxine, duloxetine) and buspirone; all with large trial bases.
- This peptide has no Western approval or RCT.
