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SEMAX + SELANK

Two Russian nootropic peptides in one vial, Semax (stimulating: focus, clarity, drive) and Selank (calming: anti-anxiety). Together they give clear-headed calm focus, Selank takes the edge off Semax’s stimulation. Dose in the morning; usable SubQ or intranasal.

Research referenceCommunity compiled

Composition

What is in the vial, and what each component targets.

50 / 50 ratio2 components · amounts as labelled
CompoundAmountTarget / pathway
SEMAX50%BDNF / TrkB pathway
Selank50%GABA-A modulation

How the blend is built

Equal parts of each peptide. The ratio is fixed; the total strength depends on the vial size you order.

Ratio as specified. Per-vial amounts vary with vial size.
Research & reference information

This profile compiles research and community-sourced reference information for educational purposes. Information may evolve as research and community knowledge develop. It is not individualized medical advice.

Overview

Semax + Selank is the ultimate dual-peptide nootropic stack combining the cognitive-enhancing drive of Semax with the calm, anxiolytic composure of Selank.

What problem it targets: It targets the "tired but wired" executive state—high anxiety paired with brain fog, burnout, executive dysfunction, and performance pressure.

What It Does

• Perfect cognitive synergy: Semax accelerates mental processing, memory, and dopamine drive, while Selank smoothly eliminates anxiety, tension, and mental friction.

• Elevates BDNF while modulating GABA: Stimulates robust neuroplasticity and new synaptic growth while maintaining a calm, parasympathetic nervous system baseline.

• Promotes peak "flow state" performance: Allows individuals to maintain laser-like mental focus and high productivity without the nervous jitters or anxiety common to stimulants.

• Realistic expectations: Can be administered subcutaneously or via nasal spray. Users experience clear, composed mental energy and elevated stress tolerance from the very first dose.

RECONSTITUTION, PICK YOUR ROUTE

RouteVial + solventConcentration (each)Per unit / spray
SubQ10 mg (5+5) + 1 mL BAC water5 mg/mL each1 unit = 50 mcg of each
Intranasal10 mg (5+5) + 5 mL sterile saline1 mg/mL each1 spray (100 µL) = 100 mcg of each

PROTOCOL, ONCE DAILY, AM

Route / phaseFrequencyDose (each)AmountNotes
SubQ, startDaily AM250 mcg each5uEase in; assess headache/tolerance.
SubQ, workingDaily AM500 mcg each10uStandard working dose (0.10 mL).
IntranasalDaily AM200–400 mcg each2–4 sprays1–2 sprays per nostril, alternating sides.
Off2 weeks––Tolerance prevention between blocks. Timing: morning only, Semax is stimulating, so avoid afternoon/evening dosing. Onset: Selank calm within ~20–30 min (intranasal); Semax clarity within hours; full cognitive effect builds over 2–4 weeks. A brief headache in days 1–3 is normal, a choline source (Alpha-GPC / Citicoline) helps.

SUBQ UNIT MAP (@ 5 MG/ML EACH) CYCLE & STORAGE

DrawVolumeEach peptide4 weeks on / 2 weeks off. SubQ (BAC): refrigerate, use within 28 days.
5u0.05 mL250 mcgIntranasal (saline): 36–46°F, use within 21 days; discard if cloudy. Use a calibrated nasal pump (100 µL/actuation).
10u0.10 mL500 mcg
2–4 spraysintranasal200–400 mcg By sex: Unisex nootropic pairing, no meaningful sex or cycle effect; same protocol for men and women. Avoid in pregnancy.

Handling & Stacking

Injection site
SubQ abdomen/thigh/upper arm (rotate), or intranasal (alternate nostrils each dose).
Pairs well with
BPC-157 (neurorepair); GHK-Cu (neuroprotective); Alpha-GPC / Citicoline (choline, prevents the day 1–3 headache); L-Theanine (amplifies Selank calm).
Side effects
Headache days 1–3 (Semax, resolves with choline); mild relaxation (Selank); irritability if stacked with stimulants. Generally very well tolerated.
Approved drug
No FDA-approved cognitive enhancer exists (the Semax side). For the anxiety side (Selank), approved options are SSRIs (sertraline, escitalopram), SNRIs and buspirone.

Safety & Patient Education

Contraindications
MAOI use (theoretical serotonergic interaction, Selank) Active psychosis or bipolar mania (Semax is stimulating) Pregnancy and lactation Hypersensitivity to either peptide
Warnings
Two-peptide nootropic blend, both components' cautions apply at once Semax is stimulating, no afternoon/evening dosing (insomnia) Additive overstimulation / irritability with other stimulants Russian-approved but no completed Western RCTs, evidence is limited; quality varies, request a COA
Drug interactions
MAOIs / serotonergic agents: theoretical interaction (Selank) CNS stimulants (caffeine, ADHD meds): additive overstimulation with Semax No major systemic (CYP) drug interactions documented
Labs
None routinely required, generally very well tolerated.
Stop criteria
Headache persisting past the first few days despite a choline source · new anxiety, agitation, or mood destabilization · any allergic reaction.
Patient education
  • Morning dosing only, Semax is stimulating; a brief day 1–3 headache is normal and a choline source (Alpha-GPC / Citicoline) helps.
  • Intranasal needs a calibrated pump (100 µL/actuation), discard if cloudy.
  • Russian-approved (Semax: stroke/cognition; Selank: anxiety); not FDA-approved in the West.
  • Request a COA.