Overview
The original GHRH peptide.
Tells your own pituitary to release a natural pulse of growth hormone, you make your own GH rather than injecting it.
What It Does
Sermorelin is GHRH(1–29), the active fragment of growth-hormone-releasing hormone.
It binds pituitary GHRH receptors and triggers a physiological GH pulse that is still regulated by your own feedback loop (somatostatin), so it rarely overshoots.
Was FDA-approved as Geref for pediatric GH deficiency / GH-axis testing (discontinued 2008); now compounded off-label for adults.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 2 mg | + 0.4 mL | 5 mg/mL |
| 5 mg | + 1 mL | 5 mg/mL |
| 10 mg | + 2 mL | 5 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–2 | Nightly 5×/week | 200 mcg | 5.0u Start low; assess sleep and tolerance before increasing. |
| Weeks 3–12 | Nightly 5×/week | 300 mcg | 7.5u Standard effective dose. Often paired with a GHRP for a larger combined pulse. |
| Off | 4 weeks | – | – Let the pituitary and receptors recover before the next cycle. |
8–12 weeks on / 4 weeks off.
Fasted pre-bed (largest natural GH pulse is during deep sleep). No food 60–90 min before / 60 min after, carbs and fats blunt the pulse.
human-validated (former FDA drug Geref); very short half-life (~10–20 min) so consistent nightly dosing matters.
Women make ~3× the GH of men yet have similar IGF-1, they’re less responsive, so often need a higher dose to move IGF-1. Oral estrogen blunts IGF-1 further (read it as running low); a skin patch/gel is more predictable. Men: Men convert GH to IGF-1 more efficiently and more often overshoot the age ceiling (a higher malignancy signal), aim mid-normal for age, don’t chase the Women make ~3× the GH of men yet have similar IGF-1, they’re less responsive, so often need a higher dose to move IGF-1. Oral estrogen blunts IGF-1 further (read it as running low); a skin patch/gel is more predictable. Men: Men convert GH to IGF-1 more efficiently and more often overshoot the age ceiling (a higher malignancy signal), aim mid-normal for age, don’t chase the top.
Handling & Stacking
- Deeper sleep within 1–2 weeks; recovery and body-composition changes over 8–12 weeks.
- Gentler and more physiological than injected HGH.
- Supply math 2mg → 9 vials | 5mg → 4 vials | 10mg → 2 vials (12-wk @ 300 mcg × 5/wk)
Safety & Patient Education
- IGF-1 (baseline + Week 8 + end).
- Target upper-normal for age Fasting glucose and HbA1c (baseline + end of cycle) Age-appropriate cancer screening before starting Out of range?
- IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.
