Overview
A dual GLP-1 + glucagon receptor agonist.
The GLP-1 side curbs appetite like semaglutide; the glucagon side raises energy expenditure and targets liver fat, it’s being developed primarily for fatty-liver disease (MASH).
What It Does
Survodutide activates both the GLP-1 receptor (satiety, slowed gastric emptying) and the glucagon receptor (increased energy expenditure, hepatic fat mobilization).
The glucagon component adds a metabolic-rate effect on top of appetite suppression.
Once-weekly.
Investigational; titrate carefully.
Reconstitution
| Vial Size | BAC Water / Solvent | Concentration |
|---|---|---|
| 10 mg | + 2 mL | 5 mg/mL |
Reconstitution Calculator
Enter the vial amount and diluent volume to calculate concentration. If you already have a target amount, you can also convert it to liquid volume and syringe markings. This tool does not recommend a target amount.
Enter a target amount you already have and select the syringe capacity.
Mathematical reference only. The calculator does not determine an appropriate target amount. Syringe capacity only changes the maximum volume that fits.
Protocol
| Phase | Frequency | Amount | Notes |
|---|---|---|---|
| Weeks 1–4 | Once | 0.6 mg | Intro phase, adapt to dual GLP-1 + glucagon stimulation. weekly |
| Weeks 5–8 | Once | 1.2–2.4 | Step up only if well tolerated. |
| Weeks 9–16 | Once | 3.6–4.8 | Target range. 4.8 mg/week is the trial target. |
| Maintenance | Once | 4.8–6 | 4.8 mg = Phase 2 target (NCT04667377); 6 mg = Phase 3 SYNCHRONIZE max. Do not exceed 6 mg, |
titrate over 14–20 weeks; the glucagon component makes nausea more likely than pure GLP-1, so go slowly.
same day each week, any time. Note: generally harsher on GI than mazdutide, don’t rush the ladder.
Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving. Men: In men, excess fat lowers testosterone; GLP-1 raises total testosterone, SHBG and gonadotropins as weight drops, and improves sperm and erectile function; and preserves fertility, unlike TRT (which suppresses spe Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving. Men: In men, excess fat lowers testosterone; GLP-1 raises total testosterone, SHBG and gonadotropins as weight drops, and improves sperm and erectile function; and preserves fertility, unlike TRT (which suppresses sperm).
Handling & Stacking
- Freeze-dried: -4°F.
- Reconstituted: 36–46°F.
- Best used within ~3–4 weeks, kept cold (structure-based estimate, no published data); that is close to the 28- day sterility limit, so use whichever comes first.
Safety & Patient Education
- Fasting glucose / HbA1c (baseline + periodic) Liver enzymes (often the point of therapy, track ALT/AST) Lipase if pancreatitis suspected; renal function with GI losses Resting heart rate / blood pressure Out of range?
- Rising glucose/HbA1c = sugar creeping up; rising ALT/AST = liver stress (often the point of therapy, track the trend).
